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KMID : 0665220150280040579
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Korean Journal of Food and Nutrition
2015 Volume.28 No. 4 p.579 ~ p.585
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Rutin Suppresses Neoplastic Cell Transformation by Inhibiting ERK and JNK Signaling Pathways
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Kang Nam-Joo
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Abstract
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Rutin is a well-known flavonoid found in buckwheat. Recent studies have demonstrated that the biological actions of rutin include anti-inflammatory and anti-cancer effects, but the underlying molecular mechanisms of these actions are not yet fully understood. Neoplastic cell transformation is considered a major event that contributes to carcinogenesis, and the present study aimed to determine whether rutin would exert anti-tumor effects via the inhibition of EGF. The present findings demonstrate that rutin inhibited EGF-induced neoplastic cell transformation in JB6 P+ cells primarily by suppressing activity in the MEK/ERK and MKK4/JNK pathways. On the other hand, rutin had no effect on the phosphorylation of MKK3/6 and p38. Collectively, these results suggest that rutin exerted a potent inhibitory influence on the molecular activity of the MEK/ERK and MKK4/JNK pathways and strongly attenuated EGF-induced neoplastic cell transformation. These findings provide insight into the biological actions of rutin and the molecular basis for the development of new chemoprotective agents.
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KEYWORD
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rutin, ERK, JNK,
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